陈刚

①代表性课题：

2019-2022  国家自然科学基金面上项目（动物模型）“基于抑郁症和气虚证应激共易感性的病证结合动物模型研究” 81万

2017-2019  江苏双创团队项目主持人  300万

2017-2020  国家自然科学基金委面上项目“PACAP-CREB 信号通路的越鞠丸快速抗抑郁机制研究” 60万

②代表性论文：

1. Tang J, Lu L, Wang Q, Liu H, Xue W, Zhou T, Xu L, Wang K, Wu D, Wei F, Tao W, Chen G*. Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway. Mol Neurobiol. 2020 Jul;57(7):3158-3170.

2. Huang Z, Chen J, Tang J, Xue W, Tao W, Wu H, Wang D, Chen G*. 2019 Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice. Wang X, Zou Z, Shen Q, Front Pharmacol. 2019;9:1537.

3.Chen G*, Xue WD, Zhu J 2018 Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine. Acta Pharmacol Sin. 2018 Feb 8. doi: 10.1038/aps.2017.137

4. Wu R, Zhang H, Xue W,  Zou ZL, Lu C,  Xia B, Wang W, Chen G* 2016 Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness. Prog Neuropsychopharmacol Biol Psychiatry. 28;73:11-18

5.Ren L, Tao W, Zhang H, Xue W, Tang J, Wu R, Xia B, Wu H, Chen G*. 2016 Two Standardized Fractions of Gardenia jasminoides Ellis with Rapid Antidepressant Effects Are Differentially Associated with BDNF Up-regulation in the Hippocampus. J Ethnopharmacol. 2016

6.Xue W, Wang W, Gong T, Zhang H, Tao WW, Xue l, Sun Y, Wu H, Wang F, Chen G* 2016 PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine. Sci Rep 2016，26331

7.Tang J, Xue W, Xia B, Ren L, Tao W, Chen C, Zhang H, Wu R, Wang Q, Wu H, Duan J, Chen G*. 2015 Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Sci Rep. 2015 28;5:13573.

8.Wu R, Zhu D, Xia Y, Wang H, Tao W, Xue W, Xia B, Ren L, Zhou X, Li G, Chen G*. 2015 A role of Yueju in fast-onset antidepressant action on major depressive disorder and serum BDNF expression: a randomly double-blind, fluoxetine-adjunct, placebo-controlled, pilot clinical study. Neuropsychiatr Dis Treat. 2015;11:2013-21.

9.Xue W, Zhou X, Yi N, Jiang L, Tao W, Wu R, Wang D, Jiang J, Ge X, Wang Y, Wu H, Chen G*. 2013. Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain. Evidence-Based Complementary and Alternative Medicine. 2013:184367

10.王省，陈刚，试论枢转少阳与快速抗抑郁，中医杂志，2017年第58卷第2期：174-176

11.王旭东,乔明琦,张樟进,陈刚,陈家旭,图娅.中医药治疗抑郁症的研究进展.南京中医药大学学报,2016,32(1):93-96.

12.陈茵,邹之璐,何骁隽,周欣,黄志恒,李筱琪,李文佳,张煜萱,陈刚.抑郁症气虚证候模型小鼠的药物反证与分子信号研究[J].南京中医药大学学报, 2018, 34(02): 147-151

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