何蓉蓉

职称：教授， 研究方向：中医理论基础和中药药效研究， 电子邮箱：rongronghe@jnu.edu.cn

1课题：

1) 国家自然科学基金杰出青年基金: 情志致病与疾病易感性

2) 国家重点研究计划—中医药现代化研究专项：基于血管病变的中医药防治冠心病的生物学基础研究

3) 国家自然科学基金面上项目:情志应激诱导多巴胺能神经元ferroptosis增加帕金森病“易感性”研究

4) 国家科技重大专项-重大新药创制专项：治疗帕金森病的候选新药特咖宁的研究与开发

5) 国家自然科学基金优秀青年基金: 情志致病与疾病易感性

6) 广州市民生科技攻关计划：清热消炎宁防治热疮的作用及机制研究

7) 海洋渔业科技推广方向—科技攻关与研发项目：海洋来源壳聚糖制备特咖宁药物缓释制剂的应用研究

8) 国家自然科学基金-面上项目：天然来源抗帕金森病候选药物特咖宁通过促进线粒体自噬保护多巴胺能神经元的作用机制研究

9) 国家自然科学基金-青年基金：新型SIRT3激活剂Theacrine促进线粒体脂肪酸氧化作用机理研究

10) 广东省自然科学基金“杰出青年”基金：中药及天然产物活性评价

 

②论文：

1. Sun WY, Tyurin V, Mikulska-Ruminska K, Shrivastava I, Anthonymuthu T, Zhai YJ, Pan MH, Gong HB, Lu DH, Sun J, Duan WJ, Korolev S, Abramov A, Angelova P, Miller I, Beharier O, Mao GW, Dar H, Kapralov A, Amoscato A, Hastings T, Greenamyre T, Chu C, Sadovsky Y, Bahar I, Bayir H, Tyrina Y*, He RR*,Kagan VE*. Phospholipase iPLA2β Averts Ferroptosis by Eliminating Redox Lipid Death Signal. Nat Chem Bio. 2021, 17(4): 465-476. (IF=15.04)

2. Luo X, Gong HB, Gao HY, Wu YP, Sun WY, Li ZQ, Wang G, Liu B, Liang L, Kurihara H, Duan WJ*, Li YF*, He RR*. Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Cell Death Differ. 2021, 28(6):1971-1989 (IF=15.828)

3. Zhang YH, Li YF, Wang Y, Tan L, Cao ZQ, Xie C, Xie G, Gong HB, Sun WY, Ouyang SH, Duan WJ, Lu X, Ding K, Kurihara H, Hu D*, Zhang ZM*, Abe I*, He RR*. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun. 2020 11(1):1473. (IF=14.919)

4. Luo Z, Liu LF, Jiang YN, Tang LP, Li W, Ouyang SH, Tu LF, Wu YP, Gong HB, Yan CY, Jiang S, Lu YH, Liu T, Jiang Z, Kurihara H, Yu Y, Yao XS*, Li YF*, He RR*. Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS. Signal Transduct Target Ther. 2020, 5(1):202. (IF=18.187)

5. Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D*, Li YF*, He RR*. Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone. Theranostics. 2020 Jul 11;10(20):9032-9049. doi: 10.7150/thno.46921. (IF=11.556)

6. Zhang J, Xiang H, Liu J, Chen Y,He RR*, Liu B*. Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target. Theranostics. 2020 Jul 9;10(18):8315-8342. doi: 10.7150/thno.45922. eCollection 2020. (IF=11.556)

7. Luo Z, Kuagn X, Zhou QQ, Yan CY, Li W, Gong HB, Kurihara H, Li WX*, Li YF*, He RR*. Inhibitory effects of baicalein against herpes simplex virus type 1. Acta Pharm Sin B. 2020,Dec 10(12):2323-2338. (IF=11.413)

8. Yan C, Luo Z, Li W, Li X, Dallmann R, Kurihara H*, Li YF*, He RR*. Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm Sin B. 2020 Mar 10(3):383-398. doi: 10.1016/j.apsb.2019.06.005. (IF=11.413)

9. Wang GE, Li YF, Zhai YJ, Gong L, Tian JY, Hong M, Yao N, Wu YP, Kurihara H, He RR*. Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. Metabolism. 2018, 85:227-239. (IF=8.694)

10.Li YF, Ouyang SH, Tu LF, Wang X, Yuan WL, Wang GE, Wu YP, Duan WJ, Yu HM, Fang ZZ, Kurihara H, Zhang YW*, He RR*. Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy. Theranostics. 2018; 8(20):5713-5730. (IF=11.556)

11.Deng J, Zhong YF, Wu YP, Luo Z, Sun YM, Wang GE, Kurihara H, Li YF*, He RR*. Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage. Redox Biol. 2018, 14:1-6. (IF=11.799)

 

③专利：

1) 姚新生，栗原博，何蓉蓉，戴毅，高昊. 中国专利ZL 200810219355.4(2011-06-29授权)

2) 何蓉蓉，张延延，曹云峰，等. 中国专利ZL 201010523429.0(2013-06-05授权)

3) 何蓉蓉，曹会娟，李怡芳，栗原博，严志标，彭红英，陆颂规，江涛，陈雪华. 中国专利ZL201210234027.8 (2014-07-30授权)

4) 陈河如，李怡芳，何蓉蓉. 中国专利ZL 201410723116.8(2017-02-22授权)

5) 孟鹤，谢小燕，申小花，张健，连林生，李怡芳，何蓉蓉，栗原博. 中国专利ZL 201610032196.1(2017-11-03授权)

6) 高昊，姚新生，何蓉蓉，陈国栋，周正群，王传喜，胡丹，范红霞. 中国专利ZL.201610033609.8 (2018-08-31授权)

7) 高昊，姚新生，何蓉蓉，李药兰，陈国栋，周正群，王传喜，李满妹，胡丹，范红霞. 中国专利ZL201610032769.0(2019-06-11授权)

8) 陈河如，袁盛，李艳冰，李怡芳，何蓉蓉. 中国专利ZL201710372369.9 (2019-11-08授权)

9) 何蓉蓉，朱思睿，涂龙芳，李怡芳，栗原博. 中国专利ZL201611149253.0 (2020-01-17授权)

10)陈河如，彭丽芝，李艳冰，张潮，李怡芳，何蓉蓉，张磊. 中国专利ZL201711054870.7 (2020-02-07授权)

11) 龚频，何蓉蓉，常相娜，杨文娟，王兰，赵天雷，陈福欣. 中国专利ZL 201710250574.8(2020-09-08授权)

12) 陈晓坚，江涛，彭红英，苏锐辉，何蓉蓉，李怡芳，栗原博，曾利杰，杨滨宾，陈丽斯. 中国专利ZL201810729003.7(2021-08-13授权)

13) 江涛，陈晓坚，彭红英，苏锐辉，何蓉蓉，李怡芳，栗原博，曾利杰，杨滨宾，陈丽斯. 中国专利ZL201810729004.1(2021-08-13授权)

 

④其他：

参编著作

1) Rong-Rong He, Hiroshi Kurihara.Oolong tea consumption and weight loss.In editor, Victor R. Preedy. TEA IN HEALTH AND DISEASE PREVENTION. Academic Press, Elsevier, Landon, UK, 2012.

2) 临床统计学——临床课题统计解读，副主编，河南科学技术出版社，2019

3) 铁死亡与人类健康，副主编，中国科技出版社，2021

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