Cayman Chemical FABP6兔单克隆抗体说明

Cayman Chemical FABP6兔单克隆抗体（37084）背景：

脂肪酸结合蛋白6（FABP6）是细胞内脂质结合蛋白（iLBP）家族的一员，在胆汁酸稳态中发挥作用。它由10条反平行的β链组成，形成含有脂质结合位点的β桶，主要在回肠的肠上皮细胞中表达，FABP6结合胆汁酸和脂肪酸，并与回肠胆汁酸转运蛋白相互作用，以帮助胆汁酸吸收，促进胆汁酸的细胞内运输，大肠癌患者血清FABP6水平升高，手术切除癌组织后降低。FABP6T79M与肥胖个体2型糖尿病风险降低相关。

Cayman ChemicalFABP6兔单克隆抗体（克隆201）可用于流式细胞术（FC），免疫细胞化学（ICC）和免疫荧光（IF）应用。

Cayman Chemical FABP6兔单克隆抗体技术参数：

同义词：脂肪酸结合蛋白6、肠胆汁酸结合蛋白

免疫原：重组人FABP6

配方：50或100µl蛋白A亲和纯化单克隆抗体

宿主：兔子

同种型：IgG抗体

应用：FC，ICC，IF

存储：-80℃

稳定性：≥1年

Cayman Chemical FABP6兔单克隆抗体相关文献：

1. Smathers, R.L., and Petersen, D.R. The human fatty acid-binding protein family: Evolutionary divergences and functions. Hum. Genomics 5(3), 170-191 (2011).

2. Hendrick, A.G., Müller, I., Willems, H., et al. Identification and investigation of novel binding fragments in the fatty acid binding protein 6 (FABP6). J. Med. Chem. 59(17), 8094-8102 (2016).

3. Storch, J., and McDermott, L. Structural and functional analysis of fatty acid-binding proteins. J. Lipid Res. 50 Suppl(Suppl), S126-S131 (2009).

4. Kim, K., Cistola, D.P., and Frieden, C. Intestinal fatty acid-binding protein: The structure and stability of a helix-less variant. Biochemistry 35(23), 7553-7558 (1996).

5. Habib, S.M., Zwicker, B.L., Wykes, L., et al. Sexually dimorphic response of mice to the Western-style diet caused by deficiency of fatty acid binding protein 6 (Fabp6). Physiol. Rep. 9(3), e14733 (2021).

6. Zhang, Y., Zhao, X., Deng, L., et al. High expression of FABP4 and FABP6 in patients with colorectal cancer. World J. Surg. Oncol. 17(1), 171 (2019).

7. Fisher, E., Grallert, H., Klapper, M., et al. Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals. Mol. Genet. Metab. 98(4), 400-405 (2009).